Venezuela's controversial President Hugo Chavez died after a lengthy struggle with cancer on Tuesday, throwing the already divided country into a state of uncertainty.
Vice-President Nicolas Maduro broke the news on national television. Chavez died at 4:25 p.m. local time, Maduro said, though the exact cause of death was not released.
With tears running down his face, Maduro called on Venezuelans to be "dignified inheritors of the giant man" Chavez was.
Chavez, who was one of Latin America's highest-profile leaders since he swept into office in 1998, had been struggling with cancer for almost two years and had recently undergone surgery in Cuba.
Chavez's condition had worsened in recent weeks and the leader had been completely out of the public eye. This week, he contracted a "severe infection," Venezuela's Communications Minister Ernesto Villegas said.
Chavez won re-election in October 2012, defeating Henrique Capriles in a bitter campaign. Capriles attacked Chavez's government for issues including rampant violent crime and corruption, winning about 45 per cent of the popular vote in the process.
Maduro, a loyal spokesman for Chavez, is set to lead Venezuela. The opposition, however, is expected to contest Maduro in a snap election that it argues should have been called after Chavez was unable to be sworn in on Jan. 10 as the constitution stipulates.
Shortly after his re-election, Chavez flew to Cuba for cancer treatment. It was his second major bout with the disease.
The Venezuelan government released a "proof of life" photo of Chavez in a Cuban hospital bed, smiling, with his daughters at his side, but the status of his recovery remained unclear. Chavez returned to Venezuela in February, but remained hidden from public view.
The government said Chavez was undergoing "chemotherapy of strong impact."
Chavez — a close friend of Cuban leader Fidel Castro — was known as an antagonist to the American government, though former Canadian Prime Minister Jean Chrétien remembered him fondly on CBC-TV's Power and Politics.
"He was a very colourful politician who had very different policies than many of us, but I had the privilege to meet him many times," Chrétien said.
"He did his best, even if we did not agree many times on the issues."

International community responds

  • Chavez dies
  • Venezuela's President Hugo Chavez poses with his daughters
  • Students protest demanding to know the real situation of Chavez's health
  • Campaigning for re-election
  • Election victory
  • Chavez shows off a pair of pistols
  • Venezuelan President Hugo Chavez at a 2001 ceremony in Caracas
  • Prayer at Cuban church
  • A Chavez supporter cries during a Mass ceremony
  • Chavez waves to supporters
  • Chavez arrives at a May 2011 Labour Day rally
  • Chavez, right, shakes hands with Russian Prime Minister Vladimir Putin
  • Chavez's supporters celebrate
  • Thousands of students demonstrate
  • From left to right, Presidents Evo Morales of Bolivia, Rafael Correa of Ecuador, and Chavez
  • Chavez speaks during a 2008 rally in Caracas
  • Director Oliver Stone and Chavez
  • Chavez, centre, poses with Venezuelan baseball players
  • A Venezuelan journalist holds a copy of the newspaper ‘The Reason’
  • Chavez shakes hands with Canadian Prime Minister Jean Chretien
  • Chavez addresses the Venezuelan Congress
  • Cuban President Fidel Castro, right, greets Chavez
  • Venezuelan President Hugo Chavez died on March 5, 2013. The following is a look at the controversial and powerful leader's life and times. (Jorge Silva/Reuters)
  • Chavez poses with his daughters, Maria Gabriela, left, and Rosa Virginia in Havana on Feb. 14, 2013. Chavez died a little more than three months after he underwent a fourth cancer-related operation. (Miraflores Presidential Press Office/AP)
  • Student protesters demand to know the real situation of Chavez's health, in Caracas on March 3. A government statement released a day later said a severe respiratory infection had left Chavez in a ’very delicate’ state. (Leo RamirezAFP/Getty)
  • Chavez shakes hands with supporters in Caracas on Sept. 28, 2012, while campaigning for re-election. (Miraflores Palace/Reuters)
  • Chavez waves the national flag from a balcony at Miraflores Palace in Caracas on Oct. 7, 2012, after winning re-election with 54 per cent of the vote to beat opposition challenger Henrique Capriles. (Jorge Silva/Reuters)
  • Chavez shows off a pair of pistols that belonged to Venezuelan liberator Simon Bolivar during celebrations of Bolivar's birthday in Caracas on July 24, 2012. (Juan Barreto/AFP/Getty)
  • Chavez salutes at a 2001 ceremony in Caracas. The controversial socialist leader's health deteriorated dramatically following several surgeries in Cuba due to cancer in his pelvic area. (Juan Barreto/AFP/Getty)
  • A priest holds a mass to pray for Venezuelan President Hugo Chavez in the Jesus de Miramar Church in Havana, Dec. 13, 2012. (Desmond Boylan/Reuters)
  • A Chavez supporter cries during a mass held to pray for the leader’s health on June 29, 2011, in Caracas. (Carlos Garcia Rawlins/Reuters)
  • Chavez waves to supporters during a 2011 Caracas ceremony to commemorate the ninth anniversary of his return to power after a brief coup. (Jorge Silva/Reuters)
  • Chavez arrives at a May 2011 Labour Day rally holding a sign that reads ‘I'm a socialist, oil worker and Chavista.’ (Jorge Silva/Reuters)
  • Chavez shakes hands with Russian Prime Minister Vladimir Putin, during Putin's visit to Miraflores presidential palace in Caracas on April 2, 2010. (Juan Barreto/AFP/Getty)
  • Chavez's supporters celebrate the results of a 2009 referendum that scrapped electoral term limits. (Juan Barreto/AFP/Getty)
  • Thousands of students demonstrate against the same 2009 constitutional amendment in Caracas. Chavez won the vote with 52 per cent support. (Pedro Rey/AFP/Getty)
  • From left to right, presidents Evo Morales of Bolivia, Rafael Correa of Ecuador, and Chavez in Quito, Ecuador, in 2009. (Rodrigo Buendia/AFP/Getty)
  • Chavez speaks during a 2008 rally in Caracas. (Thomas Coex/AFP/Getty)
  • Director Oliver Stone and Chavez attend the 2007 premiere of South of the Border, a documentary about South American politics, in Venice, Italy. (Getty)
  • Chavez poses with Venezuelan baseball players, left to right, Kelvim Escobar, Melvin Mora, Roger Cedeno and Edgardo Alfonso in 1999. (Matt Campbell/AFP/Getty)
  • A Venezuelan journalist holds a copy of the newspaper La Razon to protest Chavez’s mistreatment of the press after the government shut down a critical TV program in 2007. (Jean Torres/AFP/Getty)
  • Chavez shakes hands with Canadian Prime Minister Jean Chrétien in 2001 following free trade negotiations. (Shaun Best/AFP/Getty)
  • Chavez addresses the Venezuelan Congress after becoming president in 1999. Rodrigo Arangua /AFP/Getty
  • Cuban President Fidel Castro, right, greets Chavez, then a retired Venezuelan military officer, in Havana on Dec. 13, 1994. The two leaders maintain strong ties. (Adalberto Roque/AFP/Getty)
1 of 22
Prime Minister Stephen Harper released a statement offering his condolences to Venezuela's citizens.
"At this key juncture, I hope the people of Venezuela can now build for themselves a better, brighter future based on the principles of freedom, democracy, the rule of law and respect for human rights," the statement said.
U.S. President Barack Obama also issued a statement Tuesday.
"At this challenging time of President Hugo Chavez's passing, the United States reaffirms its support for the Venezuelan people and its interest in developing a constructive relationship with the Venezuelan government," it said.
Other U.S. politicians, like California Republican Congressman Ed Royce, were less than kind.
“Hugo Chavez was a tyrant who forced the people of Venezuela to live in fear," Royce said. "His death dents the alliance of anti-U.S. leftist leaders in South America. Good riddance to this dictator."
Some 190,000 Venezuelans, many of whom are anti-Chavez, live in the U.S.
UN Secretary General Ban Ki-moon extended his condolences to Chavez's family and the country of Venezuela, while Vitaly Churkin, Russia's ambassador to the UN, called Chavez's death "a tragedy."

Venezuela's leadership calls for calm

Hugo Chavez, centre, was given a hero's goodbye in Caracas before seeking cancer treatment in Cuba in 2012.Hugo Chavez, centre, was given a hero's goodbye in Caracas before seeking cancer treatment in Cuba in 2012. (Leo Ramirez/AFP/Getty)Opposition leader Capriles issued two tweets following Chavez's death, one offering his sympathy to Chavez's family and supporters and a second calling for solidarity among Venezuelans.
"In difficult times we must show our deep love and respect for our Venezuela!" Capriles tweeted, in Spanish.
Diego Molero, Venezuela's defence minister, said the military will remain loyal to the constitution in the wake of Chavez's death.
Admiral Molero appealed for "unity, tranquility and understanding" among Venezuelans, as the country finds itself without the man who led the country for more than 14 years.
Photojournalists in Venezuela captured images of riot police on the streets of Caracas, though the mourning has remained mostly peaceful. Shops and restaurants closed early in the capital and many Venezuelans hustled for home, some even breaking into a run.
Chavez supporters in Caracas broke down after hearing news of the leader's death.Chavez supporters in Caracas broke down after hearing news of the leader's death. (Carlos Garcia Rawlins/Reuters)"I feel a sorrow so big I can't speak," Yamilina Barrios, a 39-year-old clerk who works in the Industry Ministry, told The Associated Press, with her face covered in tears.
"He was the best this country had," she said.
In the only immediately known incident of political violence, a group of masked, helmeted men on motorcycles, some brandishing revolvers, attacked about 40 students who had been protesting for more than a week near the Supreme Court building to demand the government give more information about Chavez's health.
The attackers, who wore no clothing identifying any political allegiance, burned the students' tents and scattered their food just minutes after the death was announced.
With files from The Associated Press